Extrait de www.pubmed.com
Division Pathologie des Tumeurs, Faculté de Médecine, Université des Ryukyus, Okinawa 903-0215, Japon.
Les effets inhibiteurs d'un dérivé xanthone - l'alpha-mangostin brut - sur
deux différentes catégories de lésions prénéoplasiques du côlon chez le rat
induites par le 1, 2-dimethylhydrazine.
. . . Les indices d'antigènes nucléaires des cellules proliférantes des lésions
épithéliales et focales du côlon dans les groupes 2 et 3 étaient aussi
significativement plus bas que dans le groupe 1 et cet effet est dépendant de
la dose de l'alpha-mangostin brut mise en oeuvre. Cette découverte des effets
chimiopréventifs puissants de l'alpha-mangostin brut dans nos essais à court
terme de côlon-carcinogénèse suggère qu'une plus longue exposition puisse
aboutir à la suppression du développement de la tumeur.(Trad Le Quan)
Version originale :
http://www.ncbi.nlm.nih.gov/pubmed/15546251?ordinalpos=15&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum
Inhibitory effects of crude alpha-mangostin, a xanthone derivative, on two different categories of colon preneoplastic lesions induced by 1, 2-dimethylhydrazine in the rat.
Tumor Pathology Division, Faculty of Medicine, University of the Ryukyus, Okinawa 903-0215, Japan.
1: Planta Med. 2002 Nov;68(11):975-9.Links
The purpose of this study was to examine whether crude alpha-mangostin (a major xanthone derivative in mangosteen pericarp (Garcinia mangostana) has short-term chemopreventive effects on putative preneoplastic lesions involved in rat colon carcinogenesis. The crude preparation was obtained by simple recrystallization of an ethylacetate extract of mangosteen pericarps. A total of 33 five-week-old male F344 rats were randomly divided into 5 experimental groups. Rats in groups 1-3 were given a subcutaneous injection of 1,2-dimethylhydrazine (DMH)(40 mg/kg body weight) once a week for 2 weeks. Starting one week before the first injection of DMH, rats in groups 2 and 3 were fed a diet containing 0.02% and 0.05% crude alpha-mangostin, respectively, for 5 weeks. Rats in group 4 also received the diet containing 0.05% crude alpha-mangostin, while rats in group 5 served as untreated controls. The experiment was terminated 5 weeks after the start. Dietary administration of crude alpha-mangostin at both doses significantly inhibited the induction and/or development of aberrant crypt foci (ACF) (P <0.05 for 0.02% crude alpha-mangostin, P<0.01 for 0.05% crude alpha-mangostin), when compared to the DMH-treated group (group 1). Moreover, treatment of rats with 0.05% crude alpha-mangostin significantly decreased dysplastic foci (DF) (P<0.05) and beta-catenin accumulated crypts (BCAC) (P<0.05), to below the group 1 values. The proliferating cell nuclear antigen (PCNA) labeling indices of colon epithelium and focal lesions in groups 2 and 3 were also significantly lower than in group 1 and this effect occurred in a dose dependent manner of the crude alpha-mangostin. This finding that crude alpha-mangostin has potent chemopreventive effects in our short-term colon carcinogenesis bioassay system suggests that longer exposure might result in suppression of tumor development.
